Cluster-driven innovation and management in healthcare under regional and socio-economic disparities
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DOIhttp://dx.doi.org/10.21511/ppm.24(2).2026.29
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Article InfoVolume 24 2026, Issue #2, pp. 425-437
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Type of the article: Research Article
Abstract
The purpose of this study is to determine the socio-economic and demographic factors of intra-regional inequality in Kazakhstan and their implications for cluster-based innovation in healthcare. A hybrid approach has been used, consisting of a systematic review of 181 publications using the PRISMA 2020 protocol and econometric analysis of the 2001–2024 panel data for the districts of Kazakhstan, consisting of 3,842 observations. Fixed-effects, cluster-robust, and hierarchical mixed-effects models were employed using standardized variables of population size, fertility, mortality, migration, criminality, and investments. The results reveal that the strongest and most robust predictor of intra-regional inequality in Kazakhstan is investment in fixed capital (β = 0.466, p < 0.01; β = 0.399, p < 0.01). Population size has consistently negative effects on intra-regional inequality in Kazakhstan (β = –0.240 to –0.256, p < 0.05 and p < 0.01). In the multilevel model, fertility increases intra-regional inequality in Kazakhstan (β = 0.114, p < 0.01), whereas mortality and net migration decrease it (β = –0.150 and β = –0.037, p < 0.01). The model explained 37.1% of the variance in intra-regional inequality in Kazakhstan (R2 = 0.371). The results suggest that without balanced investment and territorially differentiated policies, cluster-based innovation in healthcare can even reinforce rather than alleviate regional disparities.
Acknowledgment
This paper was carried out within the framework of the following grant projects funded by the Science Committee of the Ministry of Science and Higher Education of the Republic of Kazakhstan: IRN AP26198345 “Reducing socio-economic inequality in the regions of Kazakhstan through investment in and improvement of the organization ofthe healthcare system”.
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JEL Classification (Paper profile tab)I18, O18, R58
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References35
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Tables4
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Figures2
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- Figure 1. Coefficient estimates and 95% confidence intervals for Model 2 (OLS with clustered standard errors)
- Figure 2. Coefficient estimates and 95% confidence intervals for Model 3 (hierarchical linear mixed model)
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- Table 1. Descriptive statistics
- Table 2. Regression results for Model 1 (OLS with regional fixed effects with dependent variable scale(adifwage))
- Table 3. Regression results for Model 2 (OLS with clustered standard errors)
- Table 4. Regression results for Model 3 (hierarchical linear mixed model, random intercepts)
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- Amofa-Adade, E., & Koltai, J. P. (2024). Health labor force exodus: A systematic review of drivers influencing nurses’ migration intentions from source countries. Journal of Infrastructure Policy and Development, 8(11).
- Asheim, B., & Coenen, L. (2005). Knowledge bases and regional innovation systems: Comparing Nordic clusters. Research Policy, 34(8), 1173-1190.
- Asheim, B. T., Isaksen, A., & Trippl, M. (2019). The role of the regional innovation system approach in contemporary regional policy: Is it still relevant in a globalised world? Institute for Economic Geography and GIScience, Vienna University of Economics and Business.
- Birkinshaw, J., & Gibson, C. (2004). Building ambidexterity into an organization. MIT Sloan Management Review, 45(4), 47-55.
- Bloom, D. E., Chatterji, S., Kowal, P., Lloyd-Sherlock, P., McKee, M., Rechel, B., Rosenberg, L., & Smith, J. P. (2015). Macroeconomic implications of population ageing and selected policy responses. The Lancet, 385(9968), 649-657.
- Breschi, S., & Malerba, F. (2005). Clusters, networks, and innovation. In The Oxford handbook of innovation (pp. 459-474). Oxford University Press.
- Champion, T., & Hugo, G. (2004). New forms of urbanization: Beyond the urban–rural dichotomy. Ashgate Publishing.
- Cooke, P. (2001). Regional innovation systems, clusters, and the knowledge economy. Industrial and Corporate Change, 10(4), 945-974.
- Cooke, P., Uranga, M. G., & Etxebarria, G. (1997). Regional innovation systems: Institutional and organizational dimensions. Research Policy, 26(4-5), 475-491.
- Edquist, C. (1997). Systems of innovation: Technologies, institutions, and organizations. Routledge.
- Feldman, M., & Zoller, T. D. (2012). Deal-makers in life science clusters. Industrial and Corporate Change, 21(2), 589-622.
- Glaeser, E. L., Rosenthal, S. S., & Strange, W. C. (2010). Urban economics and entrepreneurship. Journal of Urban Economics, 67(1), 1-14.
- Johnson, B., Lorenz, E., & Lundvall, B.-Å. (2003). Why all this fuss about codified and tacit knowledge? Industrial and Corporate Change, 12(2), 245-262.
- Kodama, F. (2007). Innovation system research and policy: Challenges and future. Technological Forecasting and Social Change, 74(9), 1422-1438.
- Koibichuk, V., Drozd, S., & Somogyi, A. (2022). The effectiveness of the sports management system in Europe: High achievements, public funding and a healthy lifestyle. Economics and Sociology, 15(4), 244-260.
- Lundvall, B.-Å. (2016). The learning economy and economic geography. Edward Elgar.
- Malik, A., Boyle, B., & Mitchell, R. (2017). Contextual ambidexterity and innovation in healthcare in India: The role of HRM. Personnel Review, 46(7), 1358-1380.
- Partridge, M. D., Rickman, D. S., Olfert, M. R., & Rose, N. L. (2007). The geography of American poverty. American Journal of Agricultural Economics, 89(5), 1238-1246.
- Porter, M. E. (1998). Clusters and the new economics of competition. Harvard Business Review, 76(6), 77-90.
- Rodríguez-Pose, A. (2013). Do institutions matter for regional development? Regional Studies, 47(7), 1034-1047.
- Rosenthal, S. S., & Strange, W. C. (2004). Evidence on the nature and sources of agglomeration economies. In Handbook of regional and urban economics (vol. 4, pp. 2119-2171). Elsevier.
- Roy, J. K., & Vasa, L. (2025). Financial technology and environmental, social and governance in sustainable finance: A bibliometric and thematic content analysis. Discover Sustainability, 6, Article 148.
- Rüth, M., & Teuteberg, F. (2020). Understanding healthcare 4.0. Business & Information Systems Engineering, 62(1), 5-17.
- Schwab, K. (2016). The Fourth Industrial Revolution. Crown Business.
- Scott, R. E., & Mars, M. (2015). Telehealth in the developing world. Journal of Telemedicine and Telecare, 21(1), 1-3.
- Spankulova, L., & Asanova, Z. (2024). The impact of information and communication technologies on gender aspects in the health system: A systematic review. Eurasian Journal of Gender Studies, 1(3), 5-14.
- Spankulova, L., Mukhamediyev, B., & Bukatov, Y. (2024). Peculiarities of demand for medicines and assessment of the consequences of introducing co-payment in Kazakhstan. Buketov Business Review, 11329(1), 102-110.
- Spankulova, L. S., Nuruly, Y., Kerimbayev, A. R., & Aimakhanova, A. Sh. (2021). The impact of socio-economic factors on the willingness of the population to maintain and accumulate health capital. Economy: Strategy and Practice, 16(3), 177-191.
- Tödtling, F., & Trippl, M. (2005). Comparative regional innovation systems: A conceptual framework. Regional Studies, 39(5), 673-693.
- Tóth, Á., Suta, A., Szauter, F., & Lukács, E. (2025). Quantitative analysis of green investments in European automotive companies: A digital reporting analysis. Clean Technologies and Environmental Policy, 27, 8749-8761.
- Trippl, M., Sinozic, T., & Smith, H. L. (2019). Handbook of regional innovation and growth. Edward Elgar.
- van Dijk, J. (2020). The digital divide. Polity Press.
- Vasylieva, T., Witczak-Smolnik, W., Tiutiunyk, I., & Filep, B. (2023). Social and economic determinants of quality of life: Case of European countries. Economics and Sociology, 16(4), 208-226.
- Yusuf, S. (2008). Innovation strategies for developing countries. World Bank.
- Zucker, L. G., Darby, M. R., & Armstrong, J. S. (2002). Commercialization of academic science. Research Policy, 31(5), 741-758.


